TPRG

Adebanjo Jonathan Adegbola

Dr Adebanjo Jonathan Adegbola

Dr Adebanjo Jonathan Adegbola is a Clinical Research and Product Development EDCTP Fellow at the KEMRI-Wellcome Trust Research Training Programme (KWTRP), Kenya. He previously received an EDCTP-Preparatory Fellowship to develop expertise in malaria genomics at the University of Copenhagen, Denmark under the DEEM-FIT project.

Adebanjo holds a Ph.D. in Pharmaceutical Chemistry and he is affiliated with the Faculty of Pharmacy, Obafemi Awolowo University, Nigeria. With the expertise gained during his EDCTP fellowship at the KWTRP and University of Copenhagen, he is investigating the impact of parasite molecular signature on the efficacy of Intermittent Preventive Treatment during Pregnancy using Sulphadoxine-Pyrimethamine.

Besides, with funding from the GSK Africa Open Laboratory, Adebanjo is currently carrying out a study titled “Assessment of Drug and Diagnostic Resistance Signature in Plasmodium falciparum: Implications on Strategies for malaria control in Nigeria (ADDReSS-Malaria)”

Research Interest

  • I have investigated the influence of host genetics and pregnancy on the pharmacokinetics interaction between antiretroviral and antimalarial drugs for effective treatment of malaria of during pregnancy.
  • My current research interests include strategies to investigate the malaria parasite molecular structure and its impact on the effectiveness of antimalarial drugs including study on the effectiveness of chemoprevention among pregnant women.
  • I also focus on developing portable and cost-effective amplicon-based sequencing assay for malaria molecular surveillance (MMS) in Nigerian population.

Fellowships

  • European and Developing Countries Clinical Trial Partnership-African Research Excellence Funds (EDCTP-AREF) Preparatory Fellowship (2020-2021) at the Centre for Medical Parasitology and Immunology, University of Copenhagen, Denmark
  • Applied Pharmacometrics Fellowship, offered by Pharmacometrics Africa and Certara University, January-June 2022,
  • EDCTP Clinical Research and Product Development Fellowship (EDCTP-CRDF) at Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya (2022-2023)

Research grants

  • National Research Fund, TETfund, Nigeria. Title: Surveillance of SP-resistant falciparum malaria in Nigeria: A strategy to underpin continuous use of intermittent preventive treatment in special populations.
  • GSK Africa Open Lab Research Grant. Assessment of Drug and Diagnostic Resistance Signature in Plasmodium falciparum: Implications on Strategies for Malaria Control in Nigeria (ADDReSS-Malaria).

Collaborators

  • Omotade Ijarotimi (Obafemi Awolowo University, Osun State, Nigeria)
  • Ifeyinwa Chijioke (University of Port Harcourt, River State, Nigeria)
  • Adekemi Adebiyi (Federal Medical Centre, Keffi, Nasarawa State, Nigeria)
  • Dr G.B. V. Olatoke (Federal Teaching Hospital, Gombe)
  • Dr Michael Alifrangis (University of Copenhagen)
  • Cally Roper (London School of Hygiene and Tropical Medicine)
  • Isabella Oyier (KWTRP, Kiliffi, Kenya)

Publications

  • Adegbola AJ, Ijarotimi OA, Ubom AE et al (2023). A snapshot of the prevalence of dihydropteroate synthase-431V mutation and other sulfadoxine-pyrimethamine resistance markers in Plasmodium falciparum isolates in Nigeria. Malar J, 22(1):71. doi: 10.1186/s12936-023-04487-5.
  • Adegbola AJ., Ogboye RM., Soyinka JO and Bolaji OO (2023). A simple high-performance liquid chromatographic assay for concurrent quantification of lumefantrine and efavirenz in human plasma from malaria–HIV co-infected individuals. Futur J Pharm Sci 9, 59. https://doi.org/10.1186/s43094-023-00508-x. Egypt
  • Bamidele, O.D., Kayode, B.A., Eniayewu, O.I. Adegbola AJ, Olatoye RS Njinga NS, Abdullahi ST and Odunola-Bakare MT (2023). Quality assessment of hydroquinone, mercury, and arsenic in skin-lightening cosmetics marketed in Ilorin, Nigeria. Science Report, 3(1):20992. doi: 10.1038/s41598-023-47160-2.
  • Bamidele OD, Eniayewu OI, Adegbola AJ, Salawu KM, Njinga NS and Abdullahi, ST (2022). Evaluation of heavy metal impurities in metformin tablet brands marketed in Ilorin, Nigeria, J. Pharm. Res. Dev. & Pract, 6 (1) 12-21.
  • Adegbola AJ, Igbinoba SI, Soyinka JO, Onyeji CO (2022). Appraisal of antiretroviral herbal medicines with proven efficacy: modulation of drug-metabolizing enzymes and permeability glycoprotein activities. Journal of Herbmed Pharmacology, 11(4): 461-474. doi: 10.34172/jhp.2022.53.
  • Adebiyi OL, Kuti BP, Adegbola AJ, Odekunle J, Onuchukwu C, Oyelami OA (2022). Relationship between Maternal and infants’ serum 25-hydroxyVitamin D, Calcium and Phosphates in an exclusively breastfeeding population. Journal of Medical Sciences, 42(1): 15-21.
  • Ogundapo SS, Soniran OT, Vining-Ogu CI, Ngobidi KC, Obasi NA, Olugbue VU, Adegbola AJ, Ogundapo AF (2021). Data on pilot assessment of efficacy of artemether-lumefantrine when co-administered with ciprofloxacin in malaria-typhoid co-infected patients. Data in Brief 9;34:106732. doi: 10.1016/j.dib.2021.106732. USA
  • Oladepo M, Adegbola AJ, Soyinka JO, Onyeji CO (2021). Effect of Vernonia Amygdalina leaf on Cytochrome P450 2D6- and 3A4-Mediated Metabolism of Dextromethorphan in Healthy Nigerian Subjects. Journal of Advances in Medical and Pharmaceutical Sciences, 23(2), 22-32.
  • Faleye FJ, Soyinka JO, Omoniyi SA, Popoola OK, Adegbola AJ, Akinpelu BA and Adekeye DK (2021). Physicochemical properties, antioxidant and antimicrobial activities of Nigerian Polyfloral honey. Journal of Pharmacognosy and Phytochemistry; 10(4): 01-09.
  • Adebiyi OL, Kuti BP, Adegbola AJ, Onuchukwu C, Oyelami OA (2021). Socio-demographic and Perinatal factors associated with suboptimal Vitamin D in exclusively breastfeeding young infants in North Central Nigeria, Alexandria Journal of Paediatrics, 34(2):101-109. DOI: 10.4103/ajop.ajop_18_21.
  • Adegbola AJ, Abutaima R, Adeagbo BA, Bolarinwa RA, Olagunju AE, Siccardi M, Owen A, Bolaji O (2020). Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when co-administered with efavirenz. Pharmacogenet Genomics, 30(5):96-106. doi: 10.1097/FPC.0000000000000401.
  • Hassan IA, Adegbola AJ, Soyinka JO, Onyeji CO, Bolaji OO (2020). Post-Marketing Surveillance of Quality of Artemether Injection Marketed in South-West Nigeria. American Journal of Tropical Medicine & Hygiene, 103(3): 1258-1265. doi.org/10.4269/ajtmh.20-0190.
  • Adegbola AJ, Omotoso E, Olubiyi OO, Soyinka JO, Bolaji OO, Onyeji CO (2020). Preparation and Physicochemical Evaluation of Lumefantrine-2-Hydroxypropyl-β-cyclodextrin Binary Systems. Journal of Pharmaceutical Research International, 32(13): 92-105.
  • Eniayewu OI, Adegbola AJ, Adeagbo BA, Bolaji OO (2020). Influence of amlodipine on the disposition of quinine in healthy volunteers. American Journal of Therapeutics, 29(1): e115-e118. doi:10.1097/MJT.0000000000001249.
  • Adegbola AJ, Soyinka JO, Bolaji OO (2020). Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV co-infected women. Pharmacogenomics Journal, 21(18):1289-1297. doi: 10.2217/pgs-2020-0081
  • Adegbola AJ, Abutaima R, Olagunju AE, Ijarotimi OA, Siccardi M, Owen A, Soyinka JO, and Bolaji OO (2018). Effect of pregnancy on the dynamics of efavirenz versus lumefantrine pharmacokinetic interaction in HIV-malaria co-infection. Antimicrobial Agent and Chemotherapy, 62(10):e01252-18. doi: 10.1128/AAC.01252-18. USA
  • Oladimeji FA, Adegbola AJ, Onyeji CO (2018). Appraisal of Bioenhancers in Improving Oral Bioavailability: Applications to Herbal Medicinal Products. Journal of Pharmaceutical Research International, 24(4):1-23. India

Teaching

  • Physical and Inorganic Pharmaceutical Chemistry (PHC 201)
  • Practical Pharmaceutical Chemistry (PHC 203)
  • Selected Physicochemical Methods in Pharmaceutical (PHC 301)
  • Medicinal Chemistry I (PHC 401)
  • Medicinal Chemistry II (PHC 402)
  • Pharmaceutical Analysis and Drug Quality Control (PHC 508)
  • Chemistry of Natural Products and Newer Synthetic Drugs (PHC 601)
  • Biopharmaceutics and Relevant Pharmacokinetics (PHC 602)

Professional Membership

  • Fellow, West African Postgraduate College of Pharmacists (WAPCP)
  • Member, Pharmacogenomics Global Research Network (PGRN)
  • Member, Pharmaceutical Society of Nigeria
  • Member, Nigeria Association of Pharmacists in Academia