B.A. Adeagbo
Dr.
Dr. B .A. Adeagbo graduated from Nigeria’s premier school of pharmacy at Obafemi Awolowo University, Ile-Ife, South Western Nigeria in 2001 with a Bachelor of Pharmacy Degree (with distinction) as one of the best students in his class. He completed his MSc and Ph.D. in Pharmaceutical Chemistry in 2008 and 2014 respectively.
He is presently a lecturer in the Department of Pharmaceutical Chemistry, Obafemi Awolowo University in Ile-Ife, Nigeria. Dr. Adeagbo is a fellow of WHO/TDR and EDCTP-CDR. He is a key member of the Translational Pharmacokinetic Research group and Therapeutic Drug Monitoring team of the Obafemi Awolowo University Teaching Hospital, Ile-Ife.
He has expertise in the use of basic modeling and simulations in the prediction of dosage and adverse reactions with a special focus on the use of antimalarial, anti-infectious and anti-cancer drugs in vulnerable groups like neonates, children, pregnant women and comorbid conditions with a view to optimizing therapy in these groups. He has a keen interest in the evaluation of specially designed drug and vaccine formulations for communicable and non-communicable diseases
He also has gained experience in adjuvant-vaccine development for infectious diseases as visiting scientist in Infectious Disease Research Institute (IDRI), Seattle, USA. With Funding from European and Developing Countries Clinical Trial Partnership (EDCTP), he is presently working on optimizing stability and bio-activity of a clinical tuberculosis vaccine
Research Interest
I have a keen interest in using pharmacogenetic and pharmacometric tools to identify biomarkers that could help to monitor the clinical outcome of drugs used in chronic non-communicable diseases like cancer with a view to maximizing their use in special populations.
I am interested in the development of novel bio-analytical methods for quantification of drugs in the different matrix.
Characterization of adjuvant based Vaccine
Field-based stability study and clinical trials of vaccines stored outside the cold chain.
Research grants:
WHO Special Programme for Research and Training in Tropical Diseases Reintegration grant – $25,000.00. February 2018 – March 2019.
European and Developing Countries Clinical Trial Partnership (EDCTP) Career Development Fellowship – October 1, 2018 – September 2021.
Publications
i. Adeagbo B.A, Olugbade T.A (2012). A simple liquid chromatography method for separation of chloramphenicol palmitate and its related substances. Analytical Science Journal 1(1):42-48.
ii. Adegbola, Adebanjo J., Soyinka, Julius O., Adeagbo, Babatunde A., Igbinoba, Sharon I., Nathaniel, Thomas I (2014). Alteration of the disposition of quinine in healthy volunteers after concurrent ciprofloxacin administration. American Journal of Therapeutics. 23(2):405-409.
iii. Adeniyi Olagunju, Oluseye O. Bolaji, Alieu Amara, Catriona Waitt, Laura Else, Julius Soyinka, Babatunde Adeagbo, Ebunoluwa Adejuyigbe, Marco Siccardi, David Back, Andrew Owen, Saye Khoo (2015). Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LCMS/MS. Journal of Antimicrobial Chemotherapy 70 (2): 555-561.
iv. Adeagbo BA, Olugbade TA, Bolaji OO, Durosinmi MA (2015). A simple HPLC –UV method for pharmacokinetic studies of imatinib in the presence of common anti-malaria agents. Journal of Liquid Chromatography and Related Technologies 38(12): 1194-1198.
v. Adebanjo J. Adegbola, Julius O. Soyinka and Babatunde A. Adeagbo (2016). Simultaneous Quantification of Ciprofloxacin, Quinine and 3-hyrdoxyquinine in Human Plasma using a HPLC Method Asian Journal of Pharmaceutical Research and Health Care 8(1), 11-18.
vi. B. A. Adeagbo, O. O. Bolaji, T. A. Olugbade, M. A. Durosinmi, R. A. Bolarinwa and C. Masimirembwa (2016). Influence of CYP3A5*3 and ABCB1 C3435T on clinical outcomes and trough plasma concentrations of imatinib in Nigerians with chronic myeloid leukaemia. Journal of Clinical Pharmacy and Therapeutics, 41: 546–551
vii. Adehin A, Bolaji OO, Kennedy MA, Adeagbo BA. (2017) Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population. Polish Annals of Medicine 24 (2):144-147 DOI: 10.1016/j.poamed.2016.06.007
viii. Izevbekhai O, Adeagbo B, Olagunju A, Bolaji O (2017) Quality of artemisinin-based antimalarial drugs marketed in Nigeria. Transactions of the Royal Society of Tropical Medicine and Hygiene; 111:90–96. DOI:10.1093/trstmh/trx019.
ix. Alero Lydia Iseh, Adebanjo Jonathan Adegbola and Babatunde Ayodeji Adeagbo (2017). Pharmacokinetic Characterization of Piperaquine in Nigerian Healthy Volunteers after Co-administration with a Commercial Brand of Moringa Tea. British Journal of Pharmaceutical Research, 15(4):1-7 DOI: 10.9734/BJPR/2017/32723
x. B. A. Adeagbo, T. A. Olugbade, M. A. Durosinmi, R. A. Bolarinwa and K. Ogungbenro and O. O Bolaji (2017). Population Pharmacokinetics of Imatinib in Nigerians with Chronic Myeloid Leukemia: Clinical Implications for Dosing and Resistance. Journal of Clinical Pharmacology, 57(12) 1554–1563 DOI: 10.1002/jcph.953.
xi. Adegbola AJ, Awobusuyi OJ, Adeagbo BA, Oladokun BS, Owolabi AR, Soyinka JO (2017). Bioequivalence Study of Generic Metformin Hydrochloride in Healthy Nigerian Volunteers. Journal of Exploratory Research in Pharmacology 2(3):75–81. DOI:10.14218/JERP.2017.00010.
xii. OS Olawoye, BA Adeagbo, OO Bolaji (2017). Effects of Moringa oleifera Leaf Powder Suspension on the Pharmacokinetics of Amodiaquine in Rats. Journal of Complementary and Alternative Medical Research 2017; 3(4): 1-8
xiii. O Edema, A Adehin, BA Adeagbo, TA Olugbade (2017). Simultaneous determination of amodiaquine and pioglitazone on dried blood spots (DBS) by HPLC–DAD and its usefulness in pharmacokinetic studies, Journal of Liquid Chromatography & Related Technologies, 40:19, 997-1001
xiv. O Edema, BA Adeagbo, A Adehin, TA Olugbade (2018). Bi-directional pharmacokinetic interaction between amodiaquine and pioglitazone in healthy subjects. Journal of Clinical Pharmacology. DOI 10.1002/jcph.1108
xv. A. Adehin, B A. Adeagbo, MA. Kennedy, OO. Bolaji, TA Olugbade, RA. Bolarinwa, MA. Durosinmi (2018). Inter-individual variation in imatinib disposition: any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in Nigerian CML patients? Leukemia & Lymphoma, DOI: 10.1080/10428194.2018.1466291.
xvi. OS Olawoye, BA Adeagbo, OO Bolaji (2018). Moringa oleifera leaf powder alters the pharmacokinetics of amodiaquine in healthy human volunteers, Journal of Clinical Pharmacy and Therapeutics 43(5): 626-632
Teaching and Learning
PHC 201 Pharmaceutical Inorganic and Physical Chemistry
PHC 203 Practical Pharmaceutical Chemistry
PHC 301 Radio pharmacy and selected physicochemical methods
PHC 401 Medicinal Chemistry 1
PHC 508 Practical Pharmaceutical Analysis and Drug quality control
PHC 602 Pharmacokinetics and Drug metabolism
PHC 603 Physicochemical Methods of drug analysis
PHC 604 Advanced Laboratory course in Pharmaceutical Chemistry
Collaborators:
i. Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria:
i. Prof. M.A. Durosinmi
ii. Dr. R.A. Bolarinwa
ii. Dr. Chris Fox, Infectious Disease Research Institute, Seattle, USA.
iii. Dr Gerhardt Boukes, Afrigen Biologics and Vaccine, Cape Town South Africa.
Professional Membership
- International Chronic Myeloid Leukaemia Foundation
- International Association of Therapeutic Drug Monitoring and Clinical Toxicology
- Pharmaceutical Society of Nigeria
- Nigerian Association of Pharmacist in Academia